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| Quality Check Question | Y/N | |
|---|---|---|
| Error checking | ||
| 1 | Are there any alphabetical or non-numeric values anywhere for any cell? | Yes |
| 2 | Are there any empty cells in the dataset? | ✔ No |
| 3 | Are there any impossible values in the dataset? | ? |
| Dates and times | ||
| 4 | Does the dosing event date occur before the date of the first positive concentration value in each subject? | ✔ Yes |
| 5 | Are all dates and times in consistent format? | No |
| Covariates | ||
| 6 | Do any time-invariant covariates change over time? | ? |
| 7 | Do any time-variable covariates don’t change over time? | ? |
| 8 | Do histograms of the covariates show any multimodalities? | ? |
| 9 | Do categorical variables have the appropriate number of levels? | ? |
| Dependent variables | ||
| 10 | Are all the dependent variable (DV) values of one type? | ? |
| 11 | Are there any DV outliers? | ? |
| NONMEM specific | ||
| 12 | Are dosing records appropriately flagged in the EVID column (e.g., EVID=1)? | ? |
| 13 | Are non-dosing events appropriately flagged in the EVID column (e.g., EVID=2)? | ? |
| 14 | Are missing DV values appropriately handled? | ? |
\[\\[5mm]\]
Number of columns (total): 16
Number of rows (total): 1030
Number of unique IDs: 64
Number of observations per IDs: mean 16.09 , median 14 , min 14 , max 26
❕ There are alphabetical or non-numeric values in the dataset: in the columns DVID, SEX, STUDY, VCOR_GENOTYPE .
There are no empty cells in the dataset.
There are no NAs in the dataset.
For the impossible values check the Covariates and Dependent variable sections.
Columns specified by user: TIME
❕ Multiple time format detected: #, #.#
No date column provided
Covariates specified by user: WT, CLCR, AGE, SEX, STUDY, ECOG_STATUS, VCOR_GENOTYPE
Covariates identified to be time-invariant: WT, CLCR, AGE, SEX, STUDY, ECOG_STATUS, VCOR_GENOTYPE
Covariates identified to be time-varying: ECOG_STATUS
There are no covariates with empty cells in the dataset.
Here are spaghetti plots for the covariates that were identified identified to be time-varying.
Explore this section to address Quality Check questions 3, 9
Check boxes if everything is ok
Covariates specified as categorical: SEX , STUDY , ECOG_STATUS , VCOR_GENOTYPE
| SEX | N | fraction | N | fraction |
|---|---|---|---|---|
| female | 10 | 0.16 | 20.20 | 1 |
| male | 54 | 0.84 | 15.33 | 1 |
| STUDY | N | fraction | N | fraction |
|---|---|---|---|---|
| STD_1 | 32 | 0.5 | 16.09 | 1 |
| STD_2 | 32 | 0.5 | 16.09 | 1 |
| ECOG_STATUS | N | fraction | N | fraction |
|---|---|---|---|---|
| 0 | 19 | 0.30 | 13.47 | 0.87 |
| 1 | 21 | 0.33 | 13.38 | 0.82 |
| 2 | 31 | 0.48 | 15.90 | 0.97 |
| VCOR_GENOTYPE | N | fraction | N | fraction |
|---|---|---|---|---|
| AA | 21 | 0.33 | 16.00 | 1 |
| AG | 26 | 0.41 | 15.92 | 1 |
| GG | 17 | 0.27 | 16.47 | 1 |
Explore this section to address Quality Check questions 3, 8
Check boxes if everything is ok
Covariates specified as continuous: WT , CLCR , AGE
Explore this section to address Quality Check questions 10, 11
Check boxes if everything is ok
| DVID | STUDY | Mean | Median | Min | Max | SD | Q0.25 | Q0.75 |
|---|---|---|---|---|---|---|---|---|
| cp | STD_1 | 6.41 | 6.10 | 0.00 | 17.60 | 3.82 | 3.20 | 8.90 |
| cp | STD_2 | 6.75 | 6.75 | -3.33 | 22.00 | 5.02 | 3.04 | 9.80 |
| pca | STD_1 | 37.50 | 28.00 | 9.00 | 100.00 | 26.06 | 20.00 | 42.00 |
| pca | STD_2 | 37.72 | 28.60 | 4.34 | 107.82 | 25.90 | 20.68 | 42.61 |
Spaghetti Plot of DV vs TIME by IDs
NONMEM-specific columns specified by user: DVID , EVID , AMT , CMT , MDV
Explore this section to additionally address Quality Check questions 12, 13
| DVID | N | fraction | N | fraction |
|---|---|---|---|---|
| 1 | 64 | 1 | 8.84 | 0.54 |
| 2 | 64 | 1 | 7.25 | 0.46 |
| EVID | N | fraction | N | fraction |
|---|---|---|---|---|
| 0 | 64 | 1 | 15.09 | 0.94 |
| 1 | 64 | 1 | 1.00 | 0.06 |
| MDV | N | fraction | N | fraction |
|---|---|---|---|---|
| 0 | 64 | 1 | 15.09 | 0.94 |
| 1 | 64 | 1 | 1.00 | 0.06 |
| CMT | N | fraction | N | fraction |
|---|---|---|---|---|
| 1 | 64 | 1.0 | 1.00 | 0.06 |
| 2 | 32 | 0.5 | 15.09 | 0.94 |
| 4 | 32 | 0.5 | 15.09 | 0.94 |
For non-zero AMT values:
| Mean | Median | Min | Max | SD | Q0.25 | Q0.75 |
|---|---|---|---|---|---|---|
| 152.5 | 176.5 | 60 | 200 | 49.7 | 108.75 | 200 |
Groupped summary:
| AMT | N | fraction | N | fraction |
|---|---|---|---|---|
| AMT = 0 or “.” | 64 | 1 | 15.09 | 0.94 |
| AMT > 0 | 64 | 1 | 1.00 | 0.06 |
Detailed summary:
| AMT | N | fraction | N | fraction |
|---|---|---|---|---|
| 0.0 | 64 | 1.00 | 15.09 | 0.94 |
| 60.0 | 1 | 0.02 | 1.00 | 0.05 |
| 75.0 | 2 | 0.03 | 1.00 | 0.04 |
| 85.0 | 1 | 0.02 | 1.00 | 0.05 |
| 87.0 | 2 | 0.03 | 1.00 | 0.07 |
| 88.5 | 1 | 0.02 | 1.00 | 0.07 |
| 90.0 | 1 | 0.02 | 1.00 | 0.06 |
| 93.0 | 2 | 0.03 | 1.00 | 0.07 |
| 95.5 | 1 | 0.02 | 1.00 | 0.07 |
| 100.0 | 3 | 0.05 | 1.00 | 0.06 |
| 105.0 | 2 | 0.03 | 1.00 | 0.07 |
| 110.0 | 1 | 0.02 | 1.00 | 0.07 |
| 112.0 | 2 | 0.03 | 1.00 | 0.07 |
| 113.0 | 3 | 0.05 | 1.00 | 0.06 |
| 115.0 | 1 | 0.02 | 1.00 | 0.07 |
| 117.0 | 1 | 0.02 | 1.00 | 0.07 |
| 120.0 | 4 | 0.06 | 1.00 | 0.07 |
| 123.0 | 1 | 0.02 | 1.00 | 0.05 |
| 125.0 | 1 | 0.02 | 1.00 | 0.07 |
| 135.0 | 1 | 0.02 | 1.00 | 0.05 |
| 153.0 | 1 | 0.02 | 1.00 | 0.07 |
| 200.0 | 32 | 0.50 | 1.00 | 0.06 |
| EVID = 0 | EVID = 1 | |
|---|---|---|
| DVID = 1 | 7.84 | 1 |
| DVID = 2 | 7.25 | 0 |
| CMT = 1 | CMT = 2 | CMT = 4 | |
|---|---|---|---|
| DVID = 1 | 1 | 3.92 | 3.92 |
| DVID = 2 | 0 | 3.62 | 3.62 |
| MDV = 0 | MDV = 1 | |
|---|---|---|
| DVID = 1 | 7.84 | 1 |
| DVID = 2 | 7.25 | 0 |
| CMT = 1 | CMT = 2 | CMT = 4 | |
|---|---|---|---|
| EVID = 0 | 0 | 7.55 | 7.55 |
| EVID = 1 | 1 | 0.00 | 0.00 |
| MDV = 0 | MDV = 1 | |
|---|---|---|
| EVID = 0 | 15.09 | 0 |
| EVID = 1 | 0.00 | 1 |
| MDV = 0 | MDV = 1 | |
|---|---|---|
| CMT = 1 | 0.00 | 1 |
| CMT = 2 | 7.55 | 0 |
| CMT = 4 | 7.55 | 0 |
| DVID = 1 | DVID = 2 | |
|---|---|---|
| AMT = 0 or “.” | 502 | 464 |
| AMT > 0 | 64 | 0 |
| EVID = 0 | EVID = 1 | |
|---|---|---|
| AMT = 0 or “.” | 966 | 0 |
| AMT > 0 | 0 | 64 |
| CMT = 1 | CMT = 2 | CMT = 4 | |
|---|---|---|---|
| AMT = 0 or “.” | 0 | 483 | 483 |
| AMT > 0 | 64 | 0 | 0 |
| MDV = 0 | MDV = 1 | |
|---|---|---|
| AMT = 0 or “.” | 966 | 0 |
| AMT > 0 | 0 | 64 |